Welcome to the Truttmann Laboratory
The overall goal of our laboratory is to determine the impact of post-translational protein modifications (PTM) on proteostasis in the context of aging and aging-associated diseases. We are particularly interested in a novel PTM, termed AMPylation, that negatively regulates the activity of heat shock protein 70 (Hsp70) family proteins. We employ numerous genetic, biochemical as well as behavioral approaches in conjunction with several model systems (Saccharomyces cerevisiae, Caenorhabditis elegans, mice, primary human tissue) to elucidate how PTMs control chaperone activity and regulate proteostasis. We further seek to generate heavy-chain only antibody fragments (VHHs, nanobodies) to characterize and manipulate specific components of the proteostasis machinery both in vitro and in vivo.